Search results for "Emetine Hydrochloride"
showing 3 items of 3 documents
Ultrastructural pathology in emetine-induced myopathy
1988
Progressive myopathy developed in two women who consumed ipecac syrup containing emetine hydrochloride to induce vomiting as part of their anorexia nervosa. Muscle biopsy specimens were characterized by severe disruption of the sarcomeres. The ultrastructural spectrum extended from "Z-band streaming" to the formation of cytoplasmic bodies and also comprised abnormalities of the sarcotubular system, thus suggesting that muscle weakness may be related to both sarcomeric and sarcotubular lesions in this self-inflicted myopathy. It is tempting to suggest that muscle weakness may be correlated with or based on the pathology in sarcomeres and the sarcotubular system. As the myopathy is clinically…
Spectrofluorimetric determination of emetine by flow injection using barium peroxide and UV derivatization
1993
Abstract The flow-injection spectrofluorimetric determination of emetine was carried out by photoderivatization in the presence of barium peroxide, in a flow-injection assembly in which the PTFE tubing in the injection valve is helically coiled around the lamp. The sample solution merges with a barium peroxidephosphoric acid solution and then the resulting mixture is irradiated; pure distilled water is used as a carrier stream. The calibration graph is linear over the range 0.05–50 μ g ml −1 of emetine dihydrochloride. The influence of foreign compounds was studied and the method was applied to the determination of emetine in injection and human urine samples.
Experimental emetine myopathy: enzyme histochemical, electron microscopic, and immunomorphological studies.
1993
Ipecac, containing emetine hydrochloride, is used by patients with anorexia nervosa to induce vomiting. Its chronic usage may result in a myopathy and a cardiomyopathy, the former marked by cytoplasmic bodies. We studied myopathological changes after daily injections of female Wistar rats with emetine hydrochloride intraperitoneally for periods of 4, 5, 9, and 10 weeks. the extensor digitorum longus muscle and the soleus muscle showed core-like lesions, streaming of the z-discs, nemaline bodies, cytoplasmic bodies, and spheroid cytoplasmic bodies. Immunomorphological studies revealed increased amounts of desmin. During a period of repair, i.e., 2, 4, and 6 weeks after termination of emetine…